Loss of Properdin Exacerbates C3 Glomerulopathy Resulting from Factor H Deficiency
نویسندگان
چکیده
منابع مشابه
Factor H deficiency and fibrillary glomerulopathy.
A 12-month-old boy presented to a local hospital with periorbital oedema and microscopic haematuria. He was pale and hypertensive and had low serum complement C3. He was treated for and followed with the diagnosis of acute post-streptococcal glomerulonephritis. The patient’s parents were second-degree relatives of each other, but his family history was entirely negative for renal disease, hyper...
متن کاملC3 deposition glomerulopathy due to a functional factor H defect.
Factor H defect Sandra Habbig, Michael J. Mihatsch, Stefan Heinen, Bodo Beck, Mathias Emmel, Christine Skerka, Michael Kirschfink, Bernd Hoppe, Peter F. Zipfel and Christoph Licht Division of Pediatric Nephrology, Children’s Hospital of the University of Cologne, Cologne, Germany; Institute of Pathology, Basel, Switzerland; Leibniz Institute for Natural Products Research and Infection Biology, ...
متن کاملC3 glomerulopathy
C3 glomerulopathy is a recently defined entity that encompasses a group of kidney diseases caused by abnormal control of complement activation with deposition of complement component C3 in glomeruli leading to variable glomerular inflammation. Before the recognition of the unique pathogenesis of these cases, they were variably classified according to their morphological features. C3 glomerulopa...
متن کاملOverview of C3 Glomerulopathy
C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents th...
متن کاملگزارش یک مورد C3 Glomerulopathy
Complement component 3 glomerulopathy (C3G) defines a group of newly classified disorders that is due to C3 deposition in glomeruli. Very few outbreaks of this disease have been reported in the world. In this study, a 56 year old woman is reported who had complaints of weakness, abdominal pain, and skin petechiae and purpura. Laboratory tests revealed mild anemia and high serum creatinine level...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2012
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2012060571